10.00-10.05
10.05-11.00
11.00-11.15
11.15-11.30
11.30-11.45
Tribute to a distinguished Ghent University dream team: Prof. Dr. Johan Van de Voorde and Mr. André Van Baeveghem
Prof. Dr. Vincent SEUTIN – Secretary General of the Belgian Society of Physiology and Pharmacology.
Main Lecture
Autophagy, a guardian against neurodegeneration.
Prof. Dr. David RUBINSTEIN – Cambridge Institute for Medical Research, Cambridge – United Kingdom.
Oral Communications
I. COORNAERT, G. MARCASSOLI, G.R.Y. DE MEYER, W. MARTINET (UAntwerpen): Macrophage-specific RIP1 deletion reduces necrotic core formation in atherosclerotic plaques of ApoE knockout mice.
E. KANIA, B. HARLET, G. ROEST, K. WELKENHUYZEN,
E. LOBBESTAEL, V. BAEKELANDT, G. BULTYNCK, J.B. PARYS (KU Leuven)
Role of LRRK2 kinase in Ca2+-dependent autophagy.
T. VERVLOESSEM, B. SASI, D. EFREMOV, G. BULTYNCK
(KU Leuven, Rome Italy)
BDA-366, a novel Bcl-2 BH4 domain antagonist, induces apoptosis through a Bcl-2 independent mechanism in DLBCL and CLL.
BELGIAN SOCIETY OF PHYSIOLOGY AND PHARMACOLOGY NATIONAL COMMITTEE OF PHYSIOLOGY AND PHARMACOLOGY
11.45-12.00 L. VANDEN DAELE, C. BOYDENS, J. VAN DE VOORDE (UGent) Characterization of the retina-mediated relaxation: involvement of pannexins?
12.00-12.15 H. SHAKERI, A. B. GEVAERT, D. M. SCHRIJVERS, G. R.Y. DE MEYER, G. W. DE KEULENAER, K. LEMMENS, V. F. SEGERS (UAntwerpen, UZAntwerpen)
Neuregulin-1 attenuates stress-induced vascular senescence.
12.15-12.30 N. HANNING, J. HEIRBAUT, H. CEULEERS, I. GOOLAERTS,
S. FRANCQUE, H. DE SCHEPPER, J. DE MAN, B. DE WINTER (UAntwerpen, UZAntwerpen)
The role of nafamostat mesilate, a serine protease inhibitor, on visceral hypersensitivity in a post-colitis model in the rat.
12.30-14.00 Lunch – Guided Poster Session – General Assembly
Posters
(height 120 cm – width 100 cm)
1. W.J. MALAISSE, R. CRUTZEN, R. BEAUWENS (ULBruxelles) Glucose-induced increase of pancreatic islet cell volume.
2. N. BENARIBA, E. HUPKENS, K. LOUCHAMI, R. DJAZIRI, A. SENER,
W.J. MALAISSE (Tlemcen Algeria, ULBruxelles)
Stimulation by citrullus colocynthis seed extracts of insulin-producing pancreatic islet cells regeneration in streptozotocin-induced diabetic rats.
3. J. SANCHEZ-ANDRES, R. POMARES, W.J. MALAISSE (Castellan Spain, ULBruxelles)
Effects of carbamoylcholine on electrical activity of mouse pancreatic islet beta cells exposed to a physiological concentration of glucose: short-term associative memory.
4. D. GALL, A. LOBO-ANTUNES, G. DUPONT (ULBruxelles)
Tonic activation of extrasynaptic NMDA receptors decreases neuronal excitability : a modeling study.
5. P. PLAEKE, J.G. DE MAN, A. SMET, H. VAN SPAENDONCK, S. NULLENS,
P. JORENS, G. HUBENS, B. DE WINTER (UAntwerpen, UZAntwerpen)
Effect of Intestinal Alkaline Phosphatase on an impaired GI barrier during sepsis: Results in a CLP-induced murine model for sepsis.
6. B. SEITAJ, H. IVANOVA, J.B. PARYS, A. METHNER, G. BULTYNCK
(KU Leuven, Mainz Germany)
TMBIM5, a Bax Inhibitor-1-family member: a novel mitochondrial Ca2+-uptake system?
7. M. KERKHOFS, R. LA ROVERE, M. BITTREMIEUX, T. VERVLOESSEM, J.B. PARYS, G. BULTYNCK (KU Leuven)
Triggering cell death through disruption of the Bcl-2/IP3R interaction in cancer cells: discovering the mechanisms via which BIRD-2 kills diffuse large B-cell lymphoma cells.
8. J. IYYATHURAI, N. WANG, C. D’HONDT, J.X. JIANG, L. LEYBAERT,
G. BULTYNCK (KU Leuven, UGent, San Antonio USA)
Intramolecular loop/tail interactions involve the SH3 binding domain, controlling Cx43-hemichannel activity.
9. R. M.L. LA ROVERE, M. BITTREMIEUX, H. AKL, K. WELKENHUYZEN,
K. DUBRON, M. BAES, A. JANSSENS, P. VANDENBERGHE, K. RIETDORF, G. MORCIANO, P. PINTON, D. EFREMOV, K. MIKOSHIBA, M.D. BOOTMAN, H. DE SMEDT, J. B. PARYS, G. BULTYNCK (KU Leuven, Milton Keynes United Kingdom, Ferrara Italy, Trieste Italy, Saitama Japan)
Constitutive IP3 signaling underlies the sensitivity of B-cell cancers to the Bcl-2/IP3 receptor disruptor BIRD-2.
10. A. BUCKINX, D. DE BUNDEL, I. SMOLDERS (VUBrussel)
The functionality of ghrelin-R:D1R interactions in D1R-mediated kindling.
Oral Communications
14.00-14.15 J. VAN DINGENEN, R.A. LEFEBVRE (UGent)
Dimethyl fumarate attenuates murine postoperative ileus independently of heme oxygenase 1.
14.15-14.30 K. JEHASSE, L. MASSOTTE, S. RINGLET, R. VENNEKENS, T. VOETS, D. ENGEL, V. SEUTIN (ULiège, KU Leuven)
Flufenamic acid inhibits the firing of dopamine neurons by a mechanism other than TRP blockade.
14.30-14.45
14.45-15.00
15.00-15.15
15.15-15.30
H. IVANOVA, L.E. WAGNER II, A. TANIMURA, E. VANDERMARLIERE, H. DE SMEDT, L. MARTENS, D. I. YULE, J.B. PARYS, G. BULTYNCK (KU Leuven, UGent, Rochester USA, Hokkaido Japan)
IP3 and Bcl-2 mutually antagonize their impact on IP3R function by competing for the ligand-binding domain.
F. SNEYERS, T. VERVLOESSEM, M. BITTREMIEUX, G. BULTYNCK (KU Leuven)
The mechanisms underlying the sensitivity of diffuse large B-cell lymphoma cells to intracellular calcium buffering.
P. LYBAERT, J. FERREIRA, L. SALKOFF, J. RILEY, C.M. SANTI
(St. Louis USA, ULBruxelles)
Membrane potential of human sperm is sensitive to external pH and intracellular Ca2+.
G. MONACO, M. MAYBURY, N. NGUYEN, N. HALEMBA, S. VAN DEN HELM, D. MOUJALLED, S. PERCIO, A.M. JABBOUR, P. EKERT, G. DEWSON, A.H. WEI, M. GUTHRIDGE (proposed by G. BULTYNCK)
(KU Leuven, Melbourne, Australia)
The metabolic phenotype of acute myeloid leukaemia (AML) arbitrates their response to Venetoclax (ABT-199): opportunities for rational development of combination therapies.
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Coffee - Tea